Among these, known transcription factors contributing to type I and type II IFN responses which emerged as highly activated regulators in all analysis among aSLE, jSLE, and their respective healthy controls as well as comparison among SLE across different age groups, such as STAT1, STAT2, IRF3, IRF7, and IRF1 (all adj. This evidence concerns the gene IFNA1 and systemic lupus erythematosus.