Our findings lend weight to the potential clinical significance of the reported associations of elevated sgp130 levels with obesity and diabetes in some older patients23, 24, 25,28 and may suggest the use of antibiotics and fecal microbiota transplantation as potential treatments for obesity, MASLD, and impaired fasting glycemia or diabetes in some adult patients. Here, IL6ST is linked to obesity due to melanocortin 4 receptor deficiency.