Kaplan‒Meier (KM) survival analysis of the TCGA-CRC cohort revealed that only sentrin-specific protease 7 (SENP7) was significantly associated with poor prognosis and positively correlated with interleukin-10 (IL-10) expression in patients with CRC (Fig. 2B, C). This evidence concerns the gene SENP7 and colorectal carcinoma.