Additionally, analyses of 3 CRC spatial transcriptomics datasets revealed a high degree of spatial colocalization among SENP7, IL-10, and CD20 (Fig. 2E & Fig. S2A-R), suggesting a potential spatial association between SENP7-expressing B cells and IL-10 production within the tumor microenvironment. This evidence concerns the gene SENP7 and colorectal carcinoma.