To explore the effect of Meox1 in Myofbs on post-MI cardiac dysfunction, fibrosis and pathological remodeling, we generated adeno-associated virus 9 (AAV9) particles carrying the negative control shRNA or Meox1 shRNA under the control of postn promoter (AAV-postn-shNC or AAV-postn-shMeox1). Here, MEOX1 is linked to myocardial infarction.