We observed enhanced levels of ubiquitinated ATP1A1 in LAPTM4B-depleted PC9 cells (Fig. 5C) and HCC827 cells (Supplementary Fig. S7H), indicating that LAPTM4B may suppress the polyubiquitination of ATP1A1 in NSCLC cells. The gene discussed is LAPTM4B; the disease is non-small cell lung carcinoma.