Compared with the mice in the same batch that did not clear macrophages (Fig. S1), the reduction of macrophages in the liver could weaken the degree of liver fibrosis induced by IL-11 overexpression, manifested as an attenuation of increased COL1A1 and α-SMA (Fig. 7C), and a decrease in HYP elevated by IL-11 from 2.43-fold without clearance to 1.57-fold after clearance (Fig. 7D). The gene discussed is ACTA1; the disease is Hepatic fibrosis.