METTL2B and ovarian neoplasm: In lymphocytes, METTL2B promotes YTHDF2-mediated decay of cytotoxic effector transcripts such as perforin and granzyme B 115, whereas in ovarian tumor cells, METTL2B stabilizes DNA repair factors including BRCA1 and FANCD2 via IGF2BP3-dependent mRNA protection 116.