To identify inhibitors of KRAS-mutated CRC proliferation, we screened 131 pyrrolo[2,3,4-kl]acridin-1(2H)-one scaffold small molecules from our internal library against KRAS-mutant (HCT8, HCT116, SW480) and KRAS wild-type (HT29, Difi, Caco2) CRC cell lines (Figure 1J, Table S5). Here, KRAS is linked to colorectal carcinoma.