Song et al. identified that the IL-33/ST2 axis contributes to systemic lupus erythematosus (SLE) progression through a mechanism driven by the Ro60 upregulation in keratinocytes, which is activated via the PI3K/Akt and SOX17 pathways and subsequently recruits macrophages 78. Here, SOX17 is linked to systemic lupus erythematosus.