While HF-HC-fed wild-type mice showed increased expression of genes related to T-cell responses (Itgax, Gata3, Tbx21, and Tlr9) and fibrosis (Col1a1 and Timp1), genes related to the regulation of glucose and lipid metabolism (Fgf21 and Fabp4) were upregulated in Rag2-/- mice (Fig. 2H). The gene discussed is COL1A1; the disease is hydrops fetalis.