Additionally, the up-regulation of OAS2 induces apoptosis and G0/G1 phase cell cycle arrest in the gefitinib-resistant PC9/GR cell line, suggesting a promising DUXAP10-EZH2-OAS2 regulatory axis to combat gefitinib resistance in NSCLC.142. The gene discussed is DUXAP10; the disease is non-small cell lung carcinoma.