In a recent study, Ren et al (2023) have discovered that the up-regulation of the pseudooncogene-derived lncRNA double homeobox A pseudogene 10 (DUXAP10) can caused the gefitinib resistance in NSCLC cells and tissues by recruiting enhancer of zeste homolog 2 (EZH2) to the promoter region of the tumor suppressor gene 2′-5′-oligoadenylate synthetase type 2 (OAS2; a protein that binds to double-stranded RNA and plays a role in triggering the activity of RNase-L).142. The gene discussed is DUXAP10; the disease is non-small cell lung carcinoma.