PIK3C2B expression showed significant positive correlations with key EMT regulators: SNAI1 (r = 0.11, p = 0.00098), VIM (r = 0.21, p = 1e-10), ZEB1 (r = 0.37, p = 6.7e-33), and TWIST2 (r = 0.11, p = 0.00034) in TCGA lung adenocarcinoma samples (Fig. 3J). Here, TWIST2 is linked to lung adenocarcinoma.