TGFB1 and pulmonary fibrosis: Knocking out LOXL1 was also a successful way of protecting mice from TGFβ-overexpression-induced pulmonary fibrosis in vivo.195 This versatile functionality of LOXL1 has been speculated to be based on proteomic cleavage of LOXL1 by BMP1 and others196,197 into mature LOXL1 and several other fragments of varying length, with not fully defined functional profiles.198