VCAN and idiopathic pulmonary fibrosis: Other matrisomal proteins that are upregulated in IPF include tenascin-C180 and versican, which can be found in the vicinity of myofibroblasts in early fibrotic foci in IPF but do not seem to be specific to IPF, but more broadly involved in fibrotic pulmonary diseases78,181 by regulating inflammatory processes.182