FBLN5 and asthma: ,126 In contrast, fibulin-5 seems to perpetuate fibrosis, at least in part, independently of TGFβ by increasing tissue stiffness,127 with results from asthma patients suggesting a fibulin-5-mediated modulation of the YAP/TAZ and Hippo pathway based on β1 integrin binding in airway smooth muscle cells.128