LAMB1 and chronic obstructive pulmonary disease: ,72 Another comparative analysis of patients with end-stage lung disease showed distinctive matrisomal phenotypes for end-stage COPD compared with IPF, which had decreased cell-adhesion mediating laminins (laminin subunit beta-1 [LAMB1] and laminin subunit gamma-1 [LAMC1]) and increased collagen VI, suggesting altered adhesion between cells and the ECM as an important aspect of the underlying pathophysiology of IPF.68