RA susceptibility is strongly linked to human leukocyte antigen (HLA) class 2 gene mutations, which encode proteins that present extracellular antigens to CD4+ T helper cells, which can influence the production of autoantibodies like ACPA [4]. Additionally, environmental factors such as smoking and silica dust are considered risk factors for the development of RA, both of which can interact with HLA alleles and lead to autoantibody production. The gene discussed is CD4; the disease is rheumatoid arthritis.