The T allele of MTHFR c.677C>T and the G allele of MTRR c.66A>Gwere significantly more common in CHD cases (OR= 1.73, 95%CI: 1.3-2.2 and OR= 1.85, 95%CI: 1.4-2.3, respectively) compared to controls. This evidence concerns the gene MTHFR and coronary artery disorder.