Vascular Ehlers-Danlos syndrome, resulting from mutations in the COL3A1 gene, and Loeys-Dietz syndrome, linked to TGFBR1 and TGFBR2 mutations, are known to predispose individuals to arterial dissections due to connective tissue fragility [12]. The gene discussed is TGFBR1; the disease is Loeys-Dietz syndrome.