In fact, a large international study found that brain lesions are more common in AQP4-IgG+ NMOSD than previously thought, although typical spinal cord longitudinally extensive transverse myelitis and optic nerve lesions were also very prevalent.10 Interestingly, the most predominant brain imaging finding were non-specific white matter lesions, suggestive of small-vessel disease in ~20% of the patients. The gene discussed is AQP4; the disease is transverse myelitis.