Indeed, most of the core clinical characteristics necessary for a diagnosis of AQP4-IgG+ NMOSD rely on findings based on MRI.2 Here, longitudinally extensive transverse myelitis lesions of the spinal cord, as well as lesions in the optic nerve, area postrema, or medulla are common.7 Recent findings have also shown that brain lesions are more prevalent than previously assumed and affect the majority of patients.8, –10. This evidence concerns the gene AQP4 and transverse myelitis.