Gunasekaran et al. demonstrated a new N‐degron‐based strategy in which a new PROTAC exploits a new N‐degron system based on poly‐arginine (poly‐arginine) to induce the degradation of polo‐like kinase 1 (PLK1), a key driver of mitosis and tumor progression (Entry 14, Table 2). This evidence concerns the gene PLK1 and neoplasm.