Among them, stathmin 1 (STMN1), a microtubule-regulating protein that promotes microtubule depolymerization by binding to α/β-tubulin heterodimers, has been reported to be highly expressed in multiple cancers and associated with poor prognosis [10, 11], including nasopharyngeal carcinoma (NPC) [12], non-small cell lung cancer (NSCLC) [13], breast cancer [14] and hepatocellular carcinoma (HCC) [15, 16], etc. The gene discussed is STMN1; the disease is hepatocellular carcinoma.