Then, various groups of nanomaterials were co-incubated with A2780 cells to detect the anti-tumor activity, and as the result shown in Fig. 3B, the PTX/si@MPDA-PEG group exhibited the highest therapeutic benefit at all the concentrations, suggesting that STMN1 interference significantly enhanced the chemotherapeutic sensitivity of ovarian cancer cells to PTX (Fig. 3B). The gene discussed is STMN1; the disease is ovarian cancer.