These genes were implicated in key immune processes: RPS26 encodes a ribosomal protein required to protect activated T cells from p53-mediated apoptosis [50], DGKQ and SKAP2 participate in T cell receptor and integrin signaling in immune cells [51], and a rare coding mutation in SKAP2 has been linked to altered myeloid cell function in T1D [52]. This evidence concerns the gene DGKQ and type 1 diabetes mellitus.