These variants are part of a diverse regulatory landscape at this locus, with SLE variants contacting FDFT1 in naïve B cells, germinal center B cells, and microglia, and MS variants contacting FDFT1 in pancreatic cells, iPSC-derived neural progenitor cells, TFH cells and Th17 cells (Fig. 4A). This evidence concerns the gene FDFT1 and systemic lupus erythematosus.