FDFT1 and multiple sclerosis: Prior studies showed that FDFT1 is downregulated in astrocytes in both mice and humans with multiple sclerosis [64, 65], and neuronal induction of FDFT1 and squalene synthase activity contributes to myelination in mouse models of chronic demyelinating disease [64], however, a role for FDFT1 in the function of any of the immune cell types studied here has not been established.