TYK2 and autoimmune disease: While implicated variants were largely trait-specific, 40% of target genes of these variants (2,207 of 5,488) were implicated across more than one autoimmune disorder (Fig. 2E, detail in Additional file 2: Figure S4C), with 11 genes implicated across a maximum of 9 traits (e.g., TYK2, ICAM1, ICAM3, TNFIP3, CLEC16A, BACH2).