2 Conserved key regulatory axes: The FOXM1-KIF4A axis observed in HCC [74] and lung adenocarcinoma [118]) and the YAP/TEAD-KIF4A axis (noted in ESCC [24] and UBC [44]) exert pro-tumorigenic effects across multiple cancer types. The gene discussed is FOXM1; the disease is hepatocellular carcinoma.