Therefore, a pan-cancer perspective is crucial to understand the conserved pathways through which KIF4A drives tumorigenesis.KIF4A demonstrates significant overexpression in 18 different malignant tumours (including breast cancer, HCC, ccRCC, CRC, oesophageal cancer, etc.)116, and exhibits the following core features at a pan-cancer level: 1 Convergent regulatory pathways: KIF4A is primarily enriched in pathways related to the cell cycle, DNA replication, and immune regulation, often forming co-expression networks with genes such as CDCA5, TPX2, and FOXM175,117. Here, KIF4A is linked to nonpapillary renal cell carcinoma.