DEPDC1 interacts with KIF4A, and their co-expression promotes progression; knocking down DEPDC1 activates the Hippo pathway, inhibiting osteosarcoma (OS) malignant behaviour, while overexpressing KIF4A reverses this effect, indicating that the DEPDC1/KIF4A axis promotes OS progression by inhibiting the Hippo pathway [45]. The gene discussed is DEPDC1; the disease is osteosarcoma.