The diagnosed factor deficiencies were FI (n = 15), FV (n = 5), FV + FVIII deficiency (n = 2), FVII (n = 21), FX (n = 10), FXI (n = 7), FXII (n = 22), FXIII (n = 7), vitamin K-dependent combined coagulation factor deficiency (n = 3) (Table 1). This evidence concerns the gene F11 and complement factor I deficiency.