ERBB2 and small cell lung carcinoma: To decipher potential synergistic treatment effects by combining ERBB2 and anti-PD-1 blockade, we performed a preclinical study in an autochthonous mouse model of SCLC, in which tumors are induced upon Cre-mediated biallelic deletion of Rb1 and Trp53. We recorded the clinicopathologic parameters of SCLC bearing mice listed according to the applied therapy regimens.