From the perspective of DNA demethylation, TET2 suppresses GC chemoresistance by forming a transcriptional axis with PATZ1 to upregulate WTIP, which interacts with PP2A to inhibit AKT T308 phosphorylation and activity, reducing stemness and chemoresistance, and its silencing suggests AKT inhibitors combined with chemotherapy as a potential treatment strategy for resistant GC [84]. The gene discussed is AKT1; the disease is gastric cancer.