YAP1 and cancer: Calvo et al. demonstrated that fibroblast activation and extracellular matrix (ECM) stiffening form a mechanotransduction loop that locks YAP/TAZ in an active state, sustaining cancer-associated fibroblast (CAF) phenotypes and invasive niches YAP/TAZ integrate signals from integrins, focal adhesion kinase (FAK), Src, Rho GTPases, and Wnt destruction complex components to coordinate proliferation with mechanical inputs [174, 175].