Given its potent control over cellular growth and identity, it is unsurprising that aberrant constitutive activation of this pathway, which commonly refers to loss-of-function mutations in APC or gain-of-function mutations in CTNNB1 (the gene encoding β-catenin), is a primary etiological driver in numerous human malignancies, most notably colorectal cancer [105]. The gene discussed is APC; the disease is colorectal cancer.