Our findings indicated that the macropinocytosis inducer, MOMIPP, enhanced the internalization of MHC II molecules in mouse HCC-infiltrating macrophages and promoted their localization within the endoplasmic reticulum (Calnexin), Golgi apparatus (GM130), endosomes (EEA1), and lysosomes (LAMP1) (Fig. 7A, S6A–S6D). This evidence concerns the gene LAMP1 and hepatocellular carcinoma.