Our findings indicated that the macropinocytosis inducer, MOMIPP, enhanced the internalization of MHC II molecules in mouse HCC-infiltrating macrophages and promoted their localization within the endoplasmic reticulum (Calnexin), Golgi apparatus (GM130), endosomes (EEA1), and lysosomes (LAMP1) (Fig. 7A, S6A–S6D). Here, EEA1 is linked to hepatocellular carcinoma.