Rescue experiments indicated Rnaseh2c-KO enhanced phosphorylation of mTOR, S6, and S6K in mouse HCC-infiltrating macrophages, whereas Traf3ip1-cKI diminished this positive effect (Fig. 2E), suggesting RNASEH2C inhibited the mTOR pathway by promoting TRAF3IP1 expression. Here, RPS6KB1 is linked to hepatocellular carcinoma.