It has been assumed that ferroptosis triggered by induction of NCOA4-mediated ferritinophagy is a significant factor in the pathogenesis of neurodegenerative diseases (del Quiles and Mancias 2019)and ferroptosis inhibitors showed beneficial effects in CPZ demyelination model and a chronic experimental autoimmune encephalomyelitis (EAE) model of MS (Jhelum et al. 2020, 2023). This evidence concerns the gene NCOA4 and neurodegenerative disease.