CPZ and myeloid sarcoma: The deleterious impact of CPZ is linked to the suppression of copper-dependent enzymes in the mitochondria participating in the electron transport chain, resulting in an increase in lipid peroxidation (LPO) products such as acrolein, malondialdehyde (MDA) and 4-hydroxy-2-nonenal (4-HNE) in oligodendrocytes, triggering oligodendrocyte damage, astrogliosis, and toxic demyelination comparable to that studied in MS (Fischer et al. 2013; Signorile et al. 2020).