lncRNA LCETRL3/LCETRL4 stabilize TDP43 or EIF2S1, leading to increased levels of NOTCH1 or phosphorylated PDK1, thereby activating AKT signaling and promoting resistance to EGFR-tyrosine kinase inhibitors (TKIs) in NSCLC [103]. The gene discussed is AKT1; the disease is non-small cell lung carcinoma.