Mechanistically, enforced IGFBP4 upregulates HK2 along with other metabolic enzymes such as GLUT1, Aldolase A (ALDOA), PGK1, pyruvate kinase M2 (PKM2), phosphoinositide-dependent kinase (PDK1), thereby facilitating ATP production in lung cancer. The gene discussed is SLC2A1; the disease is lung carcinoma.