SPHK1 and neoplasm: MiR-hsa-125b-5p affects cell proliferation, migration, and invasion by targeting multiple tumor suppressor genes such as CD147 and TPD52 [16, 17], and it participates in cancer progression by targeting STAT3 [18], BMPR1B [19], VEGFA [20], SphK1 [21], CDKN2A [22], and Sema4D [23].