CKB and neoplasm: Further analyses of the dataset included comparison to the CKB and OncoKB databases, tumor subtypes harboring activating mutations and experimental validation of individually cloned mutations in two cell line models, structural modeling and analysis of functional motifs39 or autophosphorylation sites40,41 (Fig. 2d–j, Extended Data Figs. 3b–i and 4a–c, Supplementary Note and Supplementary Table 4).