To determine whether MeCP2’s role in increasing nuclear stiffness is altered in the neurological disorder Rett syndrome, we analyzed mutations and truncations known to cause the disorder, including several of the most frequent variants (R106W, R133C, T158M, R168X, R255X, R270X, and R294X; Fig. 4a)47–49. Here, MECP2 is linked to atypical Rett syndrome.