Increased expression of Sorbs3 (p = 5.5 × 10–18), Ptpre (p = 0.006) and decreased expression of Pdk4 (p = 0.048) and Dnmt3b (p = 1.2 × 10–11) in VSG GK rats further support the involvement of epigenetic mechanisms in diabetes remission and in the long-term adaptation to bariatric surgery. This evidence concerns the gene PDK4 and diabetes mellitus.