Our liver transcriptome data suggest that diabetes remission and alteration of the liver molecular clock following VSG involve epigenetic mechanisms, which we have documented in the GK strain23, through changes in the hepatic expression of several genes encoding acetyltransferases, deacetylases and lysine demethylases and methyltransferases (e.g. Hdac1, Hdac5, Hdac7, Hdac11, Kdm1a, Kdm2a, Kdm2b, Kdm3a, Kdm7a, Kmt2a, Kmt2d, Kmt5b, Setdb2). This evidence concerns the gene SETDB2 and diabetes mellitus.