INS and fatty liver disease: However, down-regulated expression of Fxr (Log2FC = − 0.378, p = 0.016) and upregulated expression of Cyp7a1 (Log2FC = + 1.440, p = 1.2 × 10–5) in liver of VSG GK rats in our study agree with improved hepatic steatosis and insulin sensitivity and increased bile acid metabolism in mice overexpressing Cyp7a148.