Indeed, injection of slc25a39 mRNA into prpf4−/− embryos partially rescued hbbe3 expression (Fig. 7G, H) and o-dianisidine staining (Fig. 7I, J), although it did not restore the external phenotypes such as microcephaly and microphthalmia (Fig. 7G-J). Here, SLC25A39 is linked to microphthalmia.