Importantly, CD11b+MHII-Ly6Chi MO-MDSC and CD11b+Ly6Ghi PMN-MDSC in tumor tissues were substantially reduced in Lyz2-Smad3 mice within EGFP+ gates, as well as in spleens and peripheral blood (Fig. 2F and Supplementary Fig. 2B, C). This evidence concerns the gene SMAD3 and neoplasm.