Consistently, m6A levels in Smad3 mRNA were significantly reduced following Mettl3 knockdown in tumor MO-MDSC (Fig. 6D), accompanied by a notable elevation in Smad3 transcription levels (Fig. 6E), while Mettl3 overexpression decreased Smad3 expression (Fig. 6F). This evidence concerns the gene METTL3 and neoplasm.