NFKB1 and Familial prostate cancer: IL-7 stimulation can trigger the activation of the AKT and NF-κB pathways in prostate cancer cells by upregulating matrix metalloproteinases and epithelial-mesenchymal transition (EMT)-related proteins, thereby promoting the degradation of the extracellular matrix, the occurrence of EMT, and the metastatic potential of tumor cells [51, 52].