GPR18 and neoplasm: Additionally, transcriptomic analysis of TAMs from scRNA-seq data showed that TAMs in the TME of mice inoculated with Il7r-WT cells highly expressed immunosuppressive signature genes (Arg1 and Vegf) and had downregulated pro-inflammatory markers (Gpr18, Fpr2, Tnf) (Fig. 4I; Supplementary Table S3), which reflects an immunosuppressive tumor phenotype [36].