Rescue experiments conclusively established the axis dependency, circPPFIA2 overexpression robustly enhanced PCa cell proliferation and migration, whereas ETS1 knockdown fully abrogated these effects (Fig. 5M−P, and Supplementary Fig. S5G–M), confirming ETS1 as the pivotal downstream effector of circPPFIA2-mediated oncogenicity. This evidence concerns the gene ETS1 and posterior cortical atrophy.