DDIT3 and cardiac hypertrophy: This apoptotic pathway is further activated in diverse hypertensive contexts, including salt‐sensitive paradigms where chronic high‐sodium intake induces concentric cardiac hypertrophy concomitant with marked upregulation of myocardial ERS biomarkers (GRP78, CHOP) [73], and in volume overload cardiomyopathy where ERS‐CHOP axis activation drives apoptotic cardiomyocyte loss [74].