AKT1 and colorectal cancer: Experimental evidence highlights TME‐driven fine‐tuning via TEX‐derived ncRNAs: miR‐21‐5p targets RhoB to relieve PI3K inhibition, activating the SP1/XBP1 axis to promote M2 polarization [61]; miR‐1290 suppresses Akt2 to enhance PD‐L1 expression, driving M2 polarization [62]; and miR‐203a‐3p/miR‐143‐3p alleviates PI3K/AKT pathway suppression by targeting SOCS3, significantly accelerating colorectal cancer liver metastasis [63].