PKM and neoplasm: For example, circSHKBP1 sponges miR‐1294 to relieve its suppression of PKM2, promoting glycolytic activity and M2 polarization of TME [125]; lncRNA ElNF1‐AS1 upregulates PKM2 by targeting miR‐4644, synergizing with HIF‐1α to enhance glycolysis and pro‐tumorigenic phenotypes in gastric cancer‐associated macrophages [126]; while lncRNA ZFPM2‐AS1 competitively binds miR‐18b‐5p to counteract PKM2 inhibition, fostering HIF‐1α‐mediated M2 polarization and tumor immune evasion [127].