RHO and cancer: Among which, M-Ras, H-Ras, and R-Ras are classical members of Ras family cancer therapy (28, 29, 30); Rap1 belongs to the Rap subfamily, which is involved in integrin activation and plays key roles in cell adhesion (4); and Rac1 is an important member of the Rho family that regulates cytoskeleton dynamics (8).