In the immune cell correlation analysis of atrial fibrillation feature genes, we observed that CXCR4 was negatively correlated with regulatory T cells and Macrophages M2, while LDHB was positively correlated with gamma delta T cells, and DPEP2 was positively correlated with CD8 T cells (Fig 5F). This evidence concerns the gene CXCR4 and atrial fibrillation.