In the selection of feature genes for atrial fibrillation, LDHB, DPEP2, BCL11B, CKAP4, RORA, PFKFB2, and CXCR4 were identified as potentially important predictors, with the model error being lowest when the number of genes reached eleven (Fig 3C, 3D). The gene discussed is DPEP2; the disease is atrial fibrillation.