Patients with upregulated levels of VEGF-A (RQ > 2; n = 35; mean = 7.06 ±5.38) in terms of tumor depth had a worse prognosis than those with normal or downregulated (RQ < 2; n = 25; mean = 1.17 ±0.48) expression levels (log-rank P = 0.0001, χ2 = 14.8; Fig. 1A). This evidence concerns the gene VEGFA and neoplasm.