While filaggrin mutation, parental allergy status, and early sensitization to common allergens are known to influence AD persistence28,32,36 and remission,11,37 other studies have found no association between AD persistence and allergen sensitivities36 or family history of allergic disease into adulthood.25 These discrepancies may result from differences in variable definitions and follow-up durations. Here, FLG is linked to Alzheimer disease.