Tumours with a high uPA/PAI-1 status were associated with advanced lymph node involvement (12.6% vs. 6.5%; OR = 2.07, 95% CI 1.224–3.488, (Table 1, Supplementary Tables S2, S3) and poorer tumour grading (33.7% vs. 13.7%; OR = 3.50, 95% CI 2.063–5.944). The gene discussed is SERPINE1; the disease is neoplasm.