Tumours with a low uPA/PAI-1 status were more likely to be sHR-positive (94.8% vs. 80.1%; OR = 4.57, 95% CI 2.939–7.897) and HER2 negative (93.5% vs. 81.5%; OR = 3.21, 95% CI 1.937–5.328). The gene discussed is ERBB2; the disease is neoplasm.