Hyponatremia, driven by neurohormonal activation (e.g., vasopressin, angiotensin II), reduced cardiac output, and impaired renal function, is more prevalent in severe RVF and predicts mortality [74, 75], as RV dysfunction exacerbates water retention and systemic congestion [76] leading to worsening hyponatremia. This evidence concerns the gene AGT and Hyponatremia.