IFITs proteins can remodel extracellular matrix (ECM) by decreasing the expression of epithelial markers such as E-cadherin and increasing the expression of interstitial markers such as N-cadherin, as well as releasing inhibitory cytokines, such as IL-1β and IL-6 that counteract T cell function and promote cancer cell migration, metastatic potential and proliferation [75]. Here, CDH1 is linked to cancer.