IFN-γ signaling in antigen-presenting cells (APCs) leads to the upregulated expression of costimulatory molecules and cytokines involved in generating effective T cell responses, such as intercellular adhesion molecule 1 (ICAM-1), CD86, IL-1β, and interleukin-12p70 (IL-12p70), facilitating the recruitment of immune effector cells to infection sites [141–143]. The gene discussed is ICAM1; the disease is infection.