For instance, in colorectal cancer research, the integration of single-cell sequencing with organoid models has revealed the pivotal role of the NLR family pyrin domain-containing 12 (NLRP12)–serine/threonine kinase 38 (STK38)–glycogen synthase kinase 3 beta (GSK3B) signaling axis in tumor development and progression [260, 446]. This evidence concerns the gene NLRP12 and neoplasm.