Additionally, in neurodegenerative disease research, brain organoid models can mimic key pathological features, amyloid β plaques and neurofibrillary tangles in Alzheimer’s disease, as well as the abnormal accumulation of synuclein alpha (SNCA/α-synuclein) in Parkinson’s disease, providing an ideal platform for studying their pathogenesis [271]. Here, SNCA is linked to neurodegenerative disease.