Phosphorylation status also affects transcriptional regulation, such as PLK1-mediated Ser326 phosphorylation of OTUD3, which stabilizes YY1 and supports tumor growth [33], or the downregulation of PCYT2, which reduces YAP1 phosphorylation, enhancing metastasis through SNAIL2 and ZEB1 activation [34]. This evidence concerns the gene YAP1 and neoplasm.