Overexpression of MGAT5-catalyzed β1,6-GlcNAc-branched N-glycans stabilizes multiple receptors including TGF-βR, EGFR, and PD-L1 by inhibiting their degradation, sustaining EMT, angiogenesis, immune suppression, and correlating with advanced CRC stage and poor prognosis. This evidence concerns the gene EGFR and colorectal carcinoma.