CD274 and gastric cancer: USP7 interacts with and stabilizes PD-L1 in gastric cancer, and that inhibition of USP7 reduces PD-L1 expression, thereby enhancing T cell-mediated tumor killing while also suppressing tumor cell proliferation via p53 stabilization, suggesting USP7 inhibitors as promising agents to improve PD-1/PD-L1 blockade efficacy [42].