Thus, to identify the mechanism by which NaAc, PBA, and NaB block the expression of these PRRs, cytokines, IFNs, and ISGs, we measured the activation of NFκB, MAPK (ERK1/2 and p38), STAT1, STAT2, and STAT3 signaling pathways in the presence and absence of these SCFAs following ZIKV infection. This evidence concerns the gene NFKB1 and Zika virus infectious disease.