For example, different species have different serum protein compositions, and some serum proteins, like albumin,30 have different levels of amino acid sequence conservation between species, which will influence protein corona formation.31 There are also significant differences in physiological architecture, like endothelial structure and tumour blood flow rate, which directly influence the extent of passive NP movement through tumour blood vessels, known as the enhanced permeability and retention (EPR) effect. This evidence concerns the gene ALB and neoplasm.