Follow up analysis including pathway enrichment (Supplementary Table 4) revealed that the 80 proteins identified by ARCHIE (including the 13 identified in trans-pQTS), are overrepresented in targets of key transcription factors like CREB1 (FDR = 4.1×10−02) and RELA (FDR = 4.2×10−02) as well as several key cancer related pathways like cAMP signaling pathway (FDR = 3.2×10−02), TNF signaling pathway (FDR = 1.5×10−02), angiogenesis (FDR = 4.5×10−02), as well as immune response (FDR = 4.7×10−06). Here, CREB1 is linked to cancer.