The 15 proteins in ARCHIE component 2 are overrepresented in targets of several key cancer related and immune process related transcription factors like E2F6 (FDR adjusted p-value = 3.74×10−02) and CREB1 (FDR adjusted p-value = 2.5×10−02; Supplementary Table 10) and were differentially expressed in populations of T cells and macrophages. Here, CREB1 is linked to cancer.