BIN1, a tau-interacting protein involved in extracellular vesicle-mediated tau trafficking and the second most strongly associated AD locus after APOE (Table 1), demonstrated negative associations with iAging3 in inhibitory neurons and with AD in excitatory neurons, but positive associations with AD in other contexts including microglia, revealing cell-type-dependent roles in EV-mediated tau propagation. This evidence concerns the gene APOE and Alzheimer disease.