NBEAL1 is a regulator of vesicular trafficking and endolysosomal function (Table 1), exhibits positive associations between gene expression and AD across six brain regions (pTWAS < 2.5 × 10−6 in AC, DLPFC, PCC, FP, STG, IFG) with stronger associations for iAging5 in the same regions (Figure 4e; also Table S14 for TWAS p-values and Table S15 for brain region abbreviations). The gene discussed is NBEAL1; the disease is Alzheimer disease.