TNIP1 shows excitatory neuron specific associations that may increase early AD vulnerability through mitophagy suppression, consistent with the mitochondrial pathway enrichment observed for iAD2 and iAging4; while KANSL1 additionally shows strong PD associations, indicating that mitochondrial dysfunction may represent a shared mechanism across neurodegenerative disorders. The gene discussed is KANSL1; the disease is Parkinson disease.