Our integration reveals that both genes connect to AD through DNE capturing vascular dysfunction: NBEAL1 associates primarily with iAging5, annotated for ER-Golgi transport failure, BBB disruption, and vascular inflammation (Figure 3); SCAP shows associations with both iAD1 (axonal transport dysfunction) and iAging5 (vascular dysfunction). This evidence concerns the gene NBEAL1 and Alzheimer disease.