BIN1 and Alzheimer disease: DNE-xQTL integration identified ten genes spanning 7 genomic loci associated with telomere length and/or AD that converge on ciliary function through two possible mechanisms: extracellular vesicle-mediated intercellular communication (BIN1, CBY1, DNAJC5, TRIM26, GGT7 via iAging3), and structural regulation of cilia and autophagy (MAP4, KIF9, SETD2, MON1A, USP19 via iAD1) (Figure 5g).