The primary cilia cluster comprises CBY1 (Tier 1) plus MAP4, BIN1, DNAJC5, TRIM26, GGT7, and four additional genes (Tiers 2–3), linking iAD1 and iAging3 to both AD and aging (telomere length) via autophagy-extracellular vesicle pathways. Here, CBY1 is linked to Alzheimer disease.