Specifically, TNIP1 expression is positively associated with AD (pTWAS = 3.2 × 10−11), iAD2 (pTWAS = 5.1 × 10−8), and iAging2 (pTWAS = 8.1 × 10−7) in excitatory neurons (Figure 4a), and the lead variant rs871269 (chr5:151052827:C>T) colocalized across these traits and two excitatory neuron eQTL datasets (Figure 4b). The gene discussed is TNIP1; the disease is Alzheimer disease.