The primary cilia cluster comprises CBY1 (Tier 1) plus MAP4, BIN1, DNAJC5, TRIM26, GGT7, and four additional genes (Tiers 2–3), linking iAD1 and iAging3 to both AD and aging (telomere length) via autophagy-extracellular vesicle pathways. This evidence concerns the gene MAP4 and Alzheimer disease.